How heavy metals affect gut health and injury
Heavy metals exposure regulates secretory lineage in intestinal injury
This work explores how exposure to heavy metals, like uranium, impacts the cells lining our intestines and contributes to gut problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11194477 on NIH RePORTER |
What this research studies
Many communities, especially near abandoned mine sites, are exposed to heavy metals in their water and dust, which can harm the gut. This project aims to understand how these heavy metals, specifically uranium, damage the intestinal lining. Researchers will look at the specific changes that happen within the intestinal cells in response to this injury. The goal is to uncover the molecular processes that lead to inflammation and other gut issues from heavy metal exposure.
Who could benefit from this research
Good fit: This foundational work is relevant to individuals living near abandoned mine sites or those with chronic exposure to heavy metals who experience intestinal inflammation or related gut issues.
Not a fit: Patients whose intestinal issues are not related to heavy metal exposure or environmental toxins may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could help us understand how environmental toxins contribute to intestinal diseases and potentially lead to new ways to protect gut health in affected communities.
How similar studies have performed: Previous work has described the negative effects of heavy metals on gut bacteria and barrier function, but the specific cellular changes within intestinal cells are largely unknown, making this a novel area of focus.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: In, Julie Goeun — University of New Mexico Health Scis Ctr
- Study coordinator: In, Julie Goeun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.