How heavy metals affect cell growth and signaling in the body
Interplay of heavy metal homeostasis and cell growth-related signaling networks
This study looks at how heavy metals can affect the way cells work and grow in children, aiming to understand how these metals impact their health and find ways to help if they are exposed to them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10890652 on NIH RePORTER |
What this research studies
This research investigates how heavy metals, which can be toxic even in small amounts, impact cellular functions and growth signaling pathways, particularly in children. The study focuses on understanding the body's response to excess heavy metals and aims to identify the molecular mechanisms involved, especially the role of the Hippo signaling pathway. By examining how these metals interfere with cellular components, the research seeks to develop therapeutic strategies to combat heavy metal-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who may be exposed to heavy metals and are at risk for related health issues.
Not a fit: Patients who are not exposed to heavy metals or do not have conditions related to heavy metal toxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions caused by heavy metal toxicity, particularly in vulnerable populations like children.
How similar studies have performed: Previous research has shown success in understanding the effects of heavy metals on cellular processes, but this specific focus on the Hippo pathway is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Wang, Wenqi — University of California-Irvine
- Study coordinator: Wang, Wenqi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.