How heavy drinking affects lungs after TB treatment in people with HIV
The Role of Alcohol Use in Lung Disease After Treatment for Active TB Disease Among Persons Living with HIV
This work looks at whether hazardous drinking makes lung problems worse after finishing TB treatment for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11146597 on NIH RePORTER |
What this research studies
If you take part, researchers will follow 200 people with HIV who have just finished treatment for pulmonary TB in Mbarara, Uganda over 18 months. They will ask about drinking habits using the AUDIT, measure exercise ability with a 6-minute walk, do breathing tests, take chest CT images, and check for ongoing lung infections. The main question is whether past-year hazardous drinking is linked to worse walking distance and lung tests after TB treatment. Results will help explain if reducing heavy drinking could lower the risk of long-term lung disability after TB.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV who have just completed treatment for pulmonary TB and are available for follow-up in Mbarara, Uganda.
Not a fit: People who do not have HIV, have not had pulmonary TB, or who live outside the study location are not likely to be included or to directly benefit from this study.
Why it matters
Potential benefit: If hazardous drinking is linked to worse lung outcomes, the findings could point to alcohol-reduction interventions to help protect lung health after TB in people with HIV.
How similar studies have performed: Prior work shows post-TB lung problems are common and alcohol harms lung immunity, but this is one of the first focused studies testing the link between hazardous drinking and post-TB lung disease specifically in people with HIV.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: So-Armah, Kaku — Boston Medical Center
- Study coordinator: So-Armah, Kaku
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.