How heat exposure affects cellular cleanup processes in aging
Hormetic regulation of autophagy in aging
This study is looking at how short bursts of heat can help our bodies clean out damaged cells better as we get older, which might lead to healthier and longer lives, and it could help find new ways to tackle age-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10982319 on NIH RePORTER |
What this research studies
This research investigates how short-term heat exposure can enhance the body's cellular cleanup process, known as autophagy, which tends to decline with age. By studying the model organism C. elegans, the research aims to understand the mechanisms behind this process and how it can lead to longer, healthier lives. The focus is on identifying specific genes and transcription factors that regulate autophagy in response to heat stress, which could provide insights into potential interventions for age-related diseases. Patients may benefit from findings that could lead to new strategies for promoting health and longevity.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals interested in age-related health improvements.
Not a fit: Patients with acute heat sensitivity or those unable to tolerate temperature changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cellular cleanup processes, potentially improving health and longevity in aging individuals.
How similar studies have performed: Previous research has shown that hormetic stress responses can lead to significant health benefits, suggesting a promising avenue for further exploration.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Kumsta, Caroline — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Kumsta, Caroline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.