How heart cells communicate and repair after injury
Mitochondria in cardiomyocyte-fibroblast transcellular cross-talk
This study looks at how heart cells talk to each other when the heart gets hurt and how healthy energy-producing parts of the cells help with this communication, which could lead to better ways to help the heart heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11127244 on NIH RePORTER |
What this research studies
This research investigates the communication between heart muscle cells (cardiomyocytes) and supporting cells (fibroblasts) during heart injury. It focuses on how intact mitochondria, the energy-producing structures in cells, play a crucial role in this signaling process. By studying different mouse models, the researchers aim to understand how these interactions change when the heart is damaged and how they can influence healing. The findings could lead to new strategies for improving heart repair and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced cardiac injury or related conditions.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance heart repair and function after injury.
How similar studies have performed: Previous research has shown promising results in understanding cell communication in heart repair, making this approach both relevant and potentially impactful.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Prasad, Sathyamangla V — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Prasad, Sathyamangla V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.