How heart cells communicate and repair after injury
Official title: Mitochondria in cardiomyocyte-fibroblast transcellular cross-talk
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11127244 · Data updated 2026-11-12
This study looks at how heart cells talk to each other when the heart gets hurt and how healthy energy-producing parts of the cells help with this communication, which could lead to better ways to help the heart heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $639,621 |
| NIH project number | 1R01HL173543-01A1 |
| Project ID | NIH-11127244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced cardiac injury or related conditions.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the communication between heart muscle cells (cardiomyocytes) and supporting cells (fibroblasts) during heart injury. It focuses on how intact mitochondria, the energy-producing structures in cells, play a crucial role in this signaling process. By studying different mouse models, the researchers aim to understand how these interactions change when the heart is damaged and how they can influence healing. The findings could lead to new strategies for improving heart repair and function.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance heart repair and function after injury.
How similar studies have gone: Previous research has shown promising results in understanding cell communication in heart repair, making this approach both relevant and potentially impactful.
Where this research is happening
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Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Prasad, Sathyamangla V — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Prasad, Sathyamangla V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.