How Heart Cells Communicate
Mechanisms of Gap Junction Regulation
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11121024
This project explores how cells in the heart communicate to understand why this process sometimes goes wrong in heart conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11121024 on ClinicalTrials.gov |
What this research studies
Our bodies rely on tiny connections, called gap junctions, for cells to share signals and nutrients. When these connections don't work right, it can lead to various health problems, including heart disease. This work focuses on understanding the specific ways these connections are controlled, especially after a heart attack. By learning how these cell communication pathways are regulated, we hope to find new ways to help hearts that are struggling.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with cardiac diseases, particularly those who have experienced a heart attack or suffer from arrhythmias.
Not a fit: Patients without cardiac diseases or those whose conditions are unrelated to cell communication pathways may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could open new avenues for developing treatments to improve heart function after damage, such as a heart attack.
How similar studies have performed: This project builds upon existing knowledge of gap junctions and their role in disease, seeking to uncover novel, specific regulatory mechanisms.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SORGEN, PAUL L — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: SORGEN, PAUL L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders