How heart cell signals affect the progression of hypertrophic cardiomyopathy linked to genetic mutations.
Signaling To and From the Vascular/Endothelial Compartment and Progression of HCM Linked to Sarcomere Mutations
This study is looking at how communication between heart cells and blood vessels affects the worsening of hypertrophic cardiomyopathy (HCM), a genetic heart condition, to find new ways to help improve heart health for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11055466 on NIH RePORTER |
What this research studies
This research investigates how signaling between heart cells and blood vessels contributes to the progression of hypertrophic cardiomyopathy (HCM), a genetic heart condition. The study focuses on understanding the role of biophysical signals in heart muscle cells and how these signals interact with the vascular system. By examining the effects of specific mutations on heart function and vascular remodeling, the research aims to identify potential therapeutic targets that could improve patient outcomes. Patients may be involved in studies that assess changes in heart function and vascular health over time.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with hypertrophic cardiomyopathy, particularly those with known sarcomere mutations.
Not a fit: Patients without a diagnosis of hypertrophic cardiomyopathy or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of hypertrophic cardiomyopathy in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of vascular signaling in heart diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Wolska, Beata M. — University of Illinois at Chicago
- Study coordinator: Wolska, Beata M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.