How heart cell growth affects heart function after a heart attack
Impact of cardiomyocyte cell cycle activity on atrial structural and functional remodeling following myocardial infarction
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11040308
This study is looking at how the activity of heart cells affects the left side of the heart after a heart attack, using a special mouse model to help find better treatments for people recovering from heart issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11040308 on ClinicalTrials.gov |
What this research studies
This research investigates how the activity of heart muscle cells (cardiomyocytes) influences the structure and function of the left atrium following a heart attack. By using a special mouse model, researchers will compare normal heart cells with those that have reduced growth activity to understand the effects on heart remodeling. The study aims to uncover the mechanisms behind changes in heart function after a myocardial infarction, which could lead to better treatments for patients. Patients may benefit from insights gained about heart recovery and potential therapies targeting heart cell activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a myocardial infarction and are interested in understanding the underlying mechanisms of heart remodeling.
Not a fit: Patients who have not had a heart attack or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and recovery after a heart attack.
How similar studies have performed: Previous research has shown promising results in understanding heart cell behavior after injury, making this approach both relevant and potentially impactful.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIELD, LOREN J — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: FIELD, LOREN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.