How H. pylori harms the stomach lining
Mechanisms of induction of gastric injury by H. pylori
This work looks at how H. pylori changes stomach cells in ways that can lead to ulcers, tissue thinning, or stomach cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11087602 on NIH RePORTER |
What this research studies
Researchers are studying how H. pylori turns down a key pump in stomach lining cells called the Na,K-ATPase and how that weakens the stomach's barrier. They will look at how the bacteria affect newly made pumps and their movement from the cell's protein factory (the ER) to the cell surface. The team will examine chemical changes to the pump and the cellular pathways that control its trafficking using lab models and human-derived samples. The goal is to connect these cellular changes to the stomach inflammation and injury seen in infected people.
Who could benefit from this research
Good fit: People infected with H. pylori or those with H. pylori–linked stomach problems (ulcers, atrophy, or early gastric changes) would be the most relevant candidates for participation or sample donation.
Not a fit: People without H. pylori infection or with unrelated digestive conditions are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new ways to protect or restore the stomach lining and help prevent H. pylori–related ulcers and some forms of stomach cancer.
How similar studies have performed: Prior studies have shown H. pylori can damage stomach cells and that eradicating the infection reduces cancer risk, but the specific role of Na,K-ATPase trafficking is a newer, less-tested idea.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Marcus, Elizabeth a. — University of California Los Angeles
- Study coordinator: Marcus, Elizabeth a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.