How gut sugars affect the microbiome in people with HIV
Glycomic Modulation of Gut Microbiome During HIV Infection
['FUNDING_R01'] · WISTAR INSTITUTE · NIH-10762419
This study is looking at how the sugars on proteins in the gut affect gut health and the balance of bacteria in people living with HIV, to help understand why some still experience inflammation and other issues even when on treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10762419 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gut glycosylation, which refers to the sugars attached to proteins, in maintaining a healthy balance between the gut and its microbiota in individuals with HIV. The study examines how changes in these sugars, particularly during HIV infection, can lead to inflammation and microbial imbalances in the gut. By analyzing biopsies from HIV-positive individuals who are on antiretroviral therapy, the researchers aim to understand the relationship between glycomic patterns and gut health, which could provide insights into persistent HIV infection and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals who are currently on antiretroviral therapy and have experienced gut health issues.
Not a fit: Patients who are not HIV-positive or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving gut health and reducing inflammation in HIV-positive patients.
How similar studies have performed: Other research has shown promising results in understanding the role of gut microbiota in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABDEL MOHSEN, MOHAMED — WISTAR INSTITUTE
- Study coordinator: ABDEL MOHSEN, MOHAMED
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Infectious Disease Pathway, Infectious Diseases, Infectious Disorder, Communicable Diseases, Disorder