How gut microbes influence inflammation in heart and metabolic diseases
Official title: Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11163175 · Data updated 2026-11-12
This study is looking at how tiny organisms in our gut and their fats might affect inflammation linked to conditions like obesity and diabetes, and it’s for anyone interested in understanding how these gut fats could help improve health and reduce inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $743,302 |
| NIH project number | 1R01HL179780-01 |
| Project ID | NIH-11163175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity, diabetes, or related cardiometabolic conditions.
✕Less likely to help
Patients without obesity or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of gut microbes and their derived lipids in chronic inflammation associated with cardiometabolic diseases like obesity and diabetes. By examining how specific gut-derived lipids, known as N-acyl amides, interact with the body's receptors, the study aims to uncover mechanisms that contribute to inflammation and metabolic dysfunction. The researchers will utilize innovative methods in preclinical mouse models to explore how increasing these lipids can potentially mitigate inflammation and improve metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic inflammation in patients with obesity and diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in metabolic diseases, suggesting that this approach could yield significant insights.
Where this research is happening
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Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Brown, Jonathan Mark — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Brown, Jonathan Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.