How gut microbes in early life affect daily rhythms and metabolism
Developmental effects of intestinal microbes on metabolic and behavioral circadian rhythms
['FUNDING_R21'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11030768
This work explores how the tiny living organisms in our gut during childhood shape our body's daily cycles and how we process food, which is important for preventing diseases like obesity.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11030768 on ClinicalTrials.gov |
What this research studies
We know that metabolic diseases, such as obesity, are becoming more common, even in children. Our bodies have natural daily rhythms, called circadian rhythms, that are key to healthy metabolism and how our gut microbes interact with us. This project aims to understand how the microbes we acquire early in life influence these daily rhythms and our metabolism. By studying these connections, we hope to uncover new ways to prevent metabolic diseases from developing.
Who could benefit from this research
Good fit: This foundational work is relevant to individuals, especially children, who are at risk for or currently living with metabolic conditions like obesity.
Not a fit: Patients seeking immediate treatment options for existing conditions may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing obesity and other metabolic diseases by targeting gut microbes in early life.
How similar studies have performed: While the general role of gut microbes and circadian rhythms is known, how early-life microbes specifically shape the metabolic circadian network remains largely unexplored, making this a novel area of focus.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEONE, VANESSA ANNE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: LEONE, VANESSA ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.