How gut immune cells respond to different environments in the intestines
Nuclear Receptor Control of T Cell Function in Discrete Intestinal Microenvironments
This study is looking at how certain immune cells in your gut work with different substances to help control inflammation and keep your immune system balanced, which could lead to better and safer treatments for people with inflammatory bowel diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project ID | NIH-10908574 on NIH RePORTER |
What this research studies
This research investigates how immune cells in the gut, specifically CD4+ T cells, interact with various substances in the small and large intestines. By examining the role of nuclear receptors in these interactions, the study aims to understand how these immune cells can regulate inflammation and immune tolerance in different intestinal environments. The researchers will explore how these immune responses can be influenced by metabolites derived from both the host and gut microbes, potentially leading to new therapies for inflammatory bowel diseases. Patients may benefit from insights that could lead to safer and more targeted treatments for their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.
Not a fit: Patients with non-inflammatory gastrointestinal conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and targeted therapies for patients with inflammatory bowel diseases.
How similar studies have performed: Previous research has shown promise in understanding immune responses in the gut, but this specific approach focusing on nuclear receptors in different intestinal environments is relatively novel.
Where this research is happening
Lebanon, United States
- Dartmouth-Hitchcock Clinic — Lebanon, United States (Active)
Researchers
- Principal investigator: Sundrud, Mark Scott — Dartmouth-Hitchcock Clinic
- Study coordinator: Sundrud, Mark Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.