How gut immune cells influence stroke outcomes
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
This research looks at how gut bacteria and a type of immune cell called dendritic cells change inflammation after an ischemic stroke to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11285327 on NIH RePORTER |
What this research studies
If you or a loved one has had an ischemic stroke, researchers will explore how intestinal microbes interact with dendritic immune cells to shape the body's inflammatory response to the brain injury. They will use laboratory models and cellular analyses to trace the signals between gut bacteria, immune cells, and the injured brain. The team will manipulate gut microbes and dendritic cell pathways to identify which changes reduce brain inflammation and improve recovery. Findings will be used to guide potential blood- or stool-based markers and new therapies that target the gut-immune connection.
Who could benefit from this research
Good fit: Ideal candidates would be people who have experienced an ischemic stroke or are at high risk and who can provide blood and stool samples or attend clinic visits for immune testing.
Not a fit: People with non-ischemic brain injuries (for example hemorrhagic stroke) or those unable or unwilling to provide biological samples or travel for visits are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could point to new ways to reduce brain damage and improve recovery after ischemic stroke by targeting gut microbes or dendritic cell signals.
How similar studies have performed: Prior animal studies have suggested gut microbes influence stroke outcomes, but translating those findings into proven human treatments remains unproven.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Anrather, Josef — Weill Medical Coll of Cornell Univ
- Study coordinator: Anrather, Josef
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.