How gut fungi influence lung immunity and diseases like asthma
Official title: Mechanistic Investigation of Gut Mycobiota in the Regulation of Lung Immunity and Disease
Funded at Ut Southwestern Medical Center · NIH-10874781 · Data updated 2026-11-12
This study is looking at how the fungi in your gut might influence your lung health, especially for people with asthma or other breathing issues, and it hopes to find new ways to improve treatment by understanding these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL157691-04 |
| Project ID | NIH-10874781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from asthma, chronic obstructive pulmonary disease (COPD), or other inflammatory airway diseases.
✕Less likely to help
Patients without any respiratory conditions or those not affected by gut-related issues may not benefit from this research.
What this research studies
This research investigates the role of gut fungi in regulating immune responses in the lungs, particularly in relation to asthma and other airway diseases. It aims to understand how changes in the gut fungal community can affect lung inflammation and immune function. By studying the interactions between gut fungi and immune cells, the research seeks to uncover the mechanisms behind these processes, which could lead to new insights into treating respiratory conditions. Patients may be involved in providing samples or data to help elucidate these relationships.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing asthma and other airway diseases by targeting gut fungi.
How similar studies have gone: Previous research has shown promising results in understanding the gut-lung axis, indicating that this approach could yield significant insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Li, Xin — Ut Southwestern Medical Center
- Study coordinator: Li, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.