How gut cells sense different food components
Mechanisms of osmosensing in GI enteroendocrine cells
['FUNDING_FELLOWSHIP'] · MAYO CLINIC ROCHESTER · NIH-10994977
This study is looking at how certain cells in your gut react to different things in the food you eat, especially how they respond to changes in the concentration of substances, which can impact conditions like irritable bowel syndrome (IBS), to help find out if changing your diet, like trying a low FODMAP diet, can make you feel better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10994977 on ClinicalTrials.gov |
What this research studies
This research investigates how gastrointestinal (GI) epithelial cells detect various components in the foods we eat, focusing on their ability to sense changes in osmolality, which can affect gut function. The study explores the role of enteroendocrine cells (EECs) in responding to both nutritive and non-nutritive stimuli, particularly in relation to conditions like irritable bowel syndrome (IBS). By understanding these mechanisms, the research aims to identify how dietary modifications, such as low FODMAP diets, can alleviate symptoms in patients with GI disorders. The approach includes examining the signaling pathways activated by different osmotic stimuli and their effects on GI motility.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience symptoms related to gastrointestinal disorders, particularly IBS.
Not a fit: Patients with gastrointestinal disorders not related to osmolality or those who do not respond to dietary modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and treatments for patients suffering from gastrointestinal disorders like IBS.
How similar studies have performed: Previous research has shown promising results in understanding the role of dietary components in managing GI disorders, suggesting that this approach could yield significant insights.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BELLAMPALLI, SHREYA — MAYO CLINIC ROCHESTER
- Study coordinator: BELLAMPALLI, SHREYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.