How gut cells manage fat absorption and metabolism
Molecular regulation of gut lipid metabolism by mTOR and autophagy proteins
This study is looking at how certain proteins in gut cells help our bodies absorb and process dietary fats, which could provide helpful information for people dealing with obesity and insulin resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10669617 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in gut cells that regulate how dietary fats are absorbed and processed. By studying cultured gut cells and mice, the researchers aim to understand how the nutrient sensor mTOR and autophagy proteins interact to influence fat metabolism. The study focuses on the mechanisms that control the formation of chylomicrons, which are essential for fat transport in the body. Patients may benefit from insights into how these processes affect conditions like obesity and insulin resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing obesity or metabolic disorders related to fat absorption.
Not a fit: Patients with metabolic conditions unrelated to fat absorption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity and related metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding fat metabolism through similar cellular mechanisms, indicating potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Singh, Rajat — University of California Los Angeles
- Study coordinator: Singh, Rajat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.