How gut cells defend against harmful microbes
Epithelial intrinsic inflammasomes direct host defense against gut microbes
['FUNDING_R01'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-10801424
This study is looking at how certain cells in your gut help keep you safe from infections caused by bad germs, like Salmonella, and it aims to find ways to improve gut health and better protect people, especially kids, from these kinds of illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-10801424 on ClinicalTrials.gov |
What this research studies
This research investigates the role of intestinal epithelial cells (IECs) in protecting the gut from infections caused by harmful microbes. It focuses on how these cells use specialized structures called inflammasomes to trigger immune responses that help fight off pathogens like Salmonella. By understanding these mechanisms, the research aims to improve our knowledge of gut health and how to better manage enteric infections, which can lead to serious health issues, especially in children.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, particularly children, who are at risk for enteric infections or suffer from related gastrointestinal issues.
Not a fit: Patients with non-infectious gastrointestinal disorders or those not affected by enteric pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating enteric infections, reducing morbidity and mortality associated with these conditions.
How similar studies have performed: Previous studies have shown promising results regarding the role of inflammasomes in immune responses, indicating that this approach has potential for significant advancements in understanding gut health.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNODLER, LEIGH — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: KNODLER, LEIGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.