How gut bacteria process dietary phenylalanine and its link to heart failure
Official title: Gut microbial dietary phenylalanine metabolism and heart failure
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11006287 · Data updated 2026-11-12
This study is looking at how what you eat and the bacteria in your gut can affect your heart health, especially in relation to heart failure, to help find new ways to understand and possibly lower your risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 5, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $711,062 |
| NIH project number | 5R01HL167831-02 |
| Project ID | NIH-11006287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for heart failure, particularly those with dietary concerns or metabolic disorders.
✕Less likely to help
Patients who are not at risk for heart failure or do not have dietary concerns may not benefit from this research.
What this research studies
This research investigates the relationship between diet, gut microbiome, and heart failure. It focuses on how the metabolism of phenylalanine, an essential amino acid found in protein, by gut bacteria can influence the risk of developing heart failure. By examining changes in gut microbial communities and their metabolic functions, the study aims to identify new biomarkers for heart failure risk and understand how dietary choices may affect disease susceptibility. The research employs both clinical observations and animal models to explore these connections.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations and treatments that help prevent heart failure.
How similar studies have gone: Other research has shown promising results in understanding the role of gut microbiota in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Hazen, Stanley L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hazen, Stanley L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.