How gut bacteria metabolites affect inflammation in the body
Official title: Understanding mechanisms by which microbially derived metabolites regulate host gut inflammation.
Funded at Stanford University · NIH-11061207 · Data updated 2026-11-12
This study is looking at how substances made by gut bacteria can affect inflammation in the body, especially how they interact with immune cells, and it's for anyone interested in understanding how diet and gut health might influence inflammatory diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32DK138598-02 |
| Project ID | NIH-11061207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as inflammatory bowel disease, cancer, or non-alcoholic fatty liver disease.
✕Less likely to help
Patients with acute inflammatory conditions that do not involve gut microbiota dysbiosis may not benefit from this research.
What this research studies
This research investigates how metabolites produced by gut bacteria influence inflammation in the body, particularly focusing on immune responses. It aims to understand the mechanisms by which these microbial-derived metabolites (MDMs) interact with immune cells, specifically macrophages, to regulate inflammation. The study will utilize advanced techniques such as metabolomics, CRISPR/Cas9 systems, and in vivo models to explore the effects of MDMs on immune pathways. By analyzing data from dietary interventions and a library of gut microbiota strains, the research seeks to identify key metabolites that could play a role in inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic inflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Robinson, Elektra Kantzari — Stanford University
- Study coordinator: Robinson, Elektra Kantzari
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.