How gut bacteria metabolites affect inflammation in the body
Understanding mechanisms by which microbially derived metabolites regulate host gut inflammation.
This study is looking at how substances made by gut bacteria can affect inflammation in the body, especially how they interact with immune cells, and it's for anyone interested in understanding how diet and gut health might influence inflammatory diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11061207 on NIH RePORTER |
What this research studies
This research investigates how metabolites produced by gut bacteria influence inflammation in the body, particularly focusing on immune responses. It aims to understand the mechanisms by which these microbial-derived metabolites (MDMs) interact with immune cells, specifically macrophages, to regulate inflammation. The study will utilize advanced techniques such as metabolomics, CRISPR/Cas9 systems, and in vivo models to explore the effects of MDMs on immune pathways. By analyzing data from dietary interventions and a library of gut microbiota strains, the research seeks to identify key metabolites that could play a role in inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as inflammatory bowel disease, cancer, or non-alcoholic fatty liver disease.
Not a fit: Patients with acute inflammatory conditions that do not involve gut microbiota dysbiosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Robinson, Elektra Kantzari — Stanford University
- Study coordinator: Robinson, Elektra Kantzari
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.