How gut bacteria interact with H. pylori to influence stomach cancer risk
Official title: Interactions Between the Microbiota and Helicobacter pylori in Gastric Carcinogenesis
Funded at Vanderbilt University Medical Center · NIH-11089480 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut and a specific germ called Helicobacter pylori might work together to increase the risk of stomach cancer, and it's for people who want to understand more about how these factors can affect their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $680,945 |
| NIH project number | 5R01CA281732-03 |
| Project ID | NIH-11089480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of H. pylori infection or those at high risk for gastric adenocarcinoma.
✕Less likely to help
Patients without H. pylori infection or those who do not have any risk factors for gastric cancer may not benefit from this research.
What this research studies
This research investigates the relationship between the gut microbiota and Helicobacter pylori, a bacterium that significantly increases the risk of gastric adenocarcinoma. By studying a unique cohort in Colombia where these infections are common, researchers will analyze clinical data and gastric tissue samples over a long period to understand how these factors contribute to cancer development. The study also includes experiments using specialized mouse models to explore the mechanisms of carcinogenesis in the presence of H. pylori and other bacteria. This comprehensive approach aims to uncover critical insights into how these interactions affect cancer risk.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing gastric cancer by targeting the interactions between gut bacteria and H. pylori.
How similar studies have gone: Previous research has shown that understanding the role of microbiota in cancer development can lead to significant advancements in prevention and treatment strategies.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Peek, Richard M. — Vanderbilt University Medical Center
- Study coordinator: Peek, Richard M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.