How gut bacteria interact with body tissues to affect healing and disease.
Official title: Microbiota and Extracellular Matrix Interactions that Drive Host Tissue Remodeling
Funded at University of Florida · NIH-10940819 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut interact with the tissues in our body and how these interactions can affect healing and overall health, so we can better understand how our gut health influences our body's repair processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 13, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $366,438 |
| NIH project number | 1R35GM155229-01 |
| Project ID | NIH-10940819 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions such as cystic fibrosis, inflammatory bowel disease, or cervical cancer.
✕Less likely to help
Patients without any microbiome-related conditions or those not experiencing tissue remodeling may not benefit from this research.
What this research studies
This research investigates the interactions between the human microbiome and the extracellular matrix (ECM) of tissues, focusing on how these interactions influence tissue remodeling and health. By using advanced laboratory techniques, including in vitro and ex vivo models, the study aims to uncover the mechanisms by which gut bacteria can affect the structure and function of human tissues. The research will explore how changes in the ECM, driven by microbial activity, can impact the behavior of host cells involved in tissue repair and disease processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to microbiome dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding microbiome interactions with host tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Porras, Ana Maria — University of Florida
- Study coordinator: Porras, Ana Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.