How gut bacteria interact with B-cell depletion in multiple sclerosis
Interactions between Gut Microbiome and B-Cell Depletion in Multiple Sclerosis
This study is looking at how the bacteria in your gut might affect the way multiple sclerosis (MS) behaves and how well treatments work, so we can find better, personalized ways to help people with MS feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10659196 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiome and B-cell depletion in individuals with multiple sclerosis (MS). The project aims to understand why patients with MS exhibit different disease characteristics and responses to treatment. By analyzing genetic, metabolomic, and immunologic data alongside clinical information, the researchers hope to develop predictive models that can guide personalized treatment strategies. The study involves collaboration with experts in genetics, immunology, and microbiome research to enhance the understanding of MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are over 21 years old.
Not a fit: Patients with other neurological disorders or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with multiple sclerosis.
How similar studies have performed: Previous research has shown promising results in understanding the microbiome's role in autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Longbrake, Erin — Yale University
- Study coordinator: Longbrake, Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.