How gut bacteria influence the development of colon polyps
The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-10926955
This study is looking at how the bacteria in your gut might influence the growth of early signs of colorectal cancer, called adenomas, to help find better ways to prevent them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10926955 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gut microbiome and the formation of colorectal adenomas, which are early lesions that can lead to colorectal cancer. The study aims to understand how the microbiome interacts with a primed colon to promote adenoma development. Using advanced techniques, including gnotobiotic mice and metagenomic analysis, researchers will explore the specific bacteria involved and their effects on tumorigenesis. The ultimate goal is to develop targeted prevention strategies based on microbiome characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of colorectal adenomas or those at high risk for colorectal cancer.
Not a fit: Patients without any history of colorectal adenomas or those not at risk for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for colorectal cancer by targeting specific gut bacteria.
How similar studies have performed: Other research has shown promising results in understanding the role of gut microbiome in colorectal cancer, indicating that this approach has potential for success.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEY, NEELENDU — FRED HUTCHINSON CANCER CENTER
- Study coordinator: DEY, NEELENDU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.