How gut bacteria influence stroke recovery through immune cells
Official title: Intestinal Microbiota Affect Stroke Outcome by Modulating the Dendritic Cell-regulatory T Cell Axis
Funded at Weill Medical Coll of Cornell Univ · NIH-10974018 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might help your immune system recover after a stroke, and it’s for anyone interested in understanding how changes in gut health could lead to better healing after such an event.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS131007-02 |
| Project ID | NIH-10974018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are interested in understanding how gut health may influence their recovery.
✕Less likely to help
Patients who have hemorrhagic strokes or other non-ischemic stroke types may not benefit from this research.
What this research studies
This research investigates the role of gut microbiota in influencing the immune response following an ischemic stroke. It focuses on how changes in gut bacteria can affect dendritic cells, which are crucial for regulating T-cell responses in the body. By using animal models, the study examines how antibiotic-induced alterations in gut microbiota can lead to better outcomes after stroke by promoting protective immune responses. The findings aim to uncover the mechanisms through which gut bacteria can modulate the immune system to improve recovery from stroke.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance recovery from stroke by targeting gut microbiota.
How similar studies have gone: Previous studies have shown promising results regarding the influence of gut microbiota on immune responses in various conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: O'cinneide, Emma — Weill Medical Coll of Cornell Univ
- Study coordinator: O'cinneide, Emma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.