How gut bacteria influence our body's defenses and inflammation
Microbiota-derived metabolites and the regulation of host immunity and inflammation
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11090345
This work explores how substances made by gut bacteria affect our immune system and inflammation, especially in allergic diseases and parasitic infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11090345 on ClinicalTrials.gov |
What this research studies
Many people worldwide suffer from parasitic worm infections, which can lead to serious health problems like malnutrition and chronic inflammation. Our body's defense against these parasites, called type 2 immune responses, is shaped by factors like diet and the substances produced by the bacteria in our gut. This research aims to understand exactly how these gut bacteria and their products influence our immune system. By uncovering these mechanisms, we hope to find better ways to treat and prevent allergic diseases and these common infections.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals experiencing allergic diseases or those affected by chronic inflammation from parasitic infections.
Not a fit: Patients without allergic conditions or parasitic infections are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating and preventing allergic diseases and parasitic infections by targeting the gut microbiome.
How similar studies have performed: The influence of diet and microbiota on immune responses is an active area of research, with growing evidence supporting their role in various health conditions.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARTIS, DAVID — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: ARTIS, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease