How gut bacteria influence gene expression in intestinal cells
Microbial regulation of intestinal epithelial gene expression
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11136418
This study is exploring how the bacteria in our gut influence the way our intestinal cells work, especially in absorbing nutrients and protecting our immune system, to help us understand how these processes might be linked to gut health and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11136418 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacteria in our intestines affect the way intestinal cells express genes that are crucial for nutrient absorption and immune defense. It focuses on understanding the balance between genes that are activated and suppressed by these microbes, particularly looking at the role of specific transcription factors. By using advanced techniques like single-cell RNA sequencing, the study aims to uncover the complex interactions between different gene pathways in maintaining gut health. This could lead to insights into how disruptions in these processes might contribute to intestinal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in gut health and microbiome interactions.
Not a fit: Patients without any gastrointestinal issues or those not interested in the role of gut bacteria in health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing intestinal diseases by targeting microbial interactions.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in health, indicating that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAWLS, JOHN F — DUKE UNIVERSITY
- Study coordinator: RAWLS, JOHN F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: burden of disease