How gut bacteria influence daily body rhythms and immune functions
Microbial regulation of mammalian circadian rhythms and the sexual dimorphism: from metabolism to immunity
This study is looking at how the bacteria in your gut can influence your body's daily rhythms, which might affect how well you absorb nutrients and fight off illness, and it's designed for anyone interested in understanding more about gut health and its impact on overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10473122 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiota and the regulation of daily biological rhythms in the intestine, focusing on how these rhythms affect nutrient absorption and immune defense. By examining the interactions between gut bacteria and intestinal cells, the study aims to uncover the mechanisms that control these processes, particularly in response to daily changes in food availability and microbial presence. The research employs advanced biological assays to analyze the metabolic and immune functions of intestinal epithelial cells over a 24-hour cycle, providing insights into how these functions are coordinated.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with digestive system disorders or metabolic diseases who are interested in understanding the role of gut microbiota in their condition.
Not a fit: Patients with no gastrointestinal issues or those not affected by metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing digestive diseases and improving overall metabolic health.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in metabolic and immune functions, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kuang, Zheng — Carnegie-Mellon University
- Study coordinator: Kuang, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.