How gut bacteria influence cancer treatment outcomes
Official title: The role of the intestinal microbiome in cancer immunotherapy
Funded at Beckman Research Institute/city of Hope · NIH-10890871 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut can help make cancer treatments work better, especially after certain types of transplants, and it’s for patients who want to improve their treatment outcomes through things like gut health and careful use of antibiotics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $1,014,601 |
| NIH project number | 5R35CA284024-03 |
| Project ID | NIH-10890871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing cancer immunotherapy or allogeneic hematopoietic cell transplantation.
✕Less likely to help
Patients who are not receiving immunotherapy or those with conditions unrelated to the microbiome's influence on cancer treatment may not benefit from this research.
What this research studies
This research investigates the role of the intestinal microbiome in enhancing the effectiveness of cancer immunotherapy, particularly after procedures like allogeneic hematopoietic cell transplantation. It examines how the composition of gut bacteria can affect immune responses, including T cell activity against tumors. The study includes clinical trials that explore interventions such as fecal microbiota transplants and careful management of antibiotic use to improve patient outcomes. By understanding these relationships, the research aims to optimize cancer treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatment outcomes by harnessing the power of the gut microbiome.
How similar studies have gone: Previous studies have shown promising results in manipulating the gut microbiome to improve cancer treatment outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Van Den Brink, Marcel R M — Beckman Research Institute/city of Hope
- Study coordinator: Van Den Brink, Marcel R M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.