How gut bacteria influence cancer caused by viruses
Virally-induced tumorigenesis controlled by the microbiota
This study is looking at how the bacteria in our gut might affect the risk of developing leukemia caused by a specific virus, and it aims to find out if changing these gut bacteria could help improve cancer outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11127148 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbiota in the development of cancer, specifically leukemia induced by the Murine Leukemia Virus (MuLV). It explores how certain gut bacteria can suppress the immune response, potentially leading to increased cancer risk. By studying mouse models, the research aims to identify specific microbial interactions that affect cancer progression and immune regulation. The findings could provide insights into how modifying gut bacteria might influence cancer outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a predisposition to cancers influenced by viral infections and gut microbiota.
Not a fit: Patients with cancers not associated with viral infections or those whose cancer is not influenced by microbiota may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancer by targeting the gut microbiota.
How similar studies have performed: Other research has shown promising results in understanding the relationship between microbiota and cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Golovkina, Tatyana V — University of Chicago
- Study coordinator: Golovkina, Tatyana V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.