How gut bacteria influence body rhythms and nutrient use
Microbiota-dependent Epigenetic Regulation of Circadian Rhythms in Nutrient Uptake and Energy Homeostasis
This study is looking at how the bacteria in your gut and your body's natural daily rhythms work together to affect how you absorb nutrients and manage energy, helping you understand how your diet and gut health can impact your overall metabolism and daily life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10654520 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiota and the body's circadian rhythms, particularly how these factors affect nutrient uptake and energy balance. By studying the interactions between gut bacteria and intestinal cells, the research aims to uncover mechanisms that regulate metabolic functions through epigenetic changes. The approach includes examining how disruptions in these interactions can lead to metabolic disorders, with a focus on histone acetylation and gene expression related to nutrient metabolism. Patients may gain insights into how their diet and gut health influence their metabolic health and daily rhythms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing metabolic syndrome or related conditions, particularly those with issues related to energy balance and dietary habits.
Not a fit: Patients who do not have metabolic syndrome or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing metabolic syndrome and improving overall health through dietary and lifestyle interventions.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kuang, Zheng — Carnegie-Mellon University
- Study coordinator: Kuang, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.