How gut bacteria influence blood cell production and immune response
Official title: Regulation of Steady-State Hematopoiesis by Microbiota-Driven IFN-I Signaling
Funded at Baylor College of Medicine · NIH-10898596 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut can influence the production of blood cells, especially when antibiotics are used, and it aims to find ways to help people who might face blood-related issues from long-term antibiotic use.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL168921-02 |
| Project ID | NIH-10898596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require long-term antibiotic treatment and are at risk for blood cell production complications.
✕Less likely to help
Patients who are not on antibiotics or do not have blood cell production issues may not benefit from this research.
What this research studies
This research investigates how the gut microbiome affects blood cell production, particularly focusing on the impact of antibiotics on bone marrow function. It aims to understand the molecular mechanisms behind antibiotic-induced bone marrow suppression, which can lead to serious conditions like neutropenia. By using a mouse model, the study explores how the microbiome supports healthy blood cell differentiation and the role of type I interferon signaling in this process. The ultimate goal is to develop therapies that can prevent or treat blood-related complications in patients requiring long-term antibiotic treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent blood cell production issues in patients on prolonged antibiotic therapy.
How similar studies have gone: Previous studies have shown that microbiome interactions can influence blood cell production, indicating potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Maknojia, Arushana Amir — Baylor College of Medicine
- Study coordinator: Maknojia, Arushana Amir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.