How gut bacteria develop and interact in newborns
Molecular interactions in the gut microbiota during early life colonization and perturbation
This study is looking at the tiny germs in the bellies of newborns to see how they start to grow and work together right after birth, which is important for keeping babies healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10891609 on NIH RePORTER |
What this research studies
This research investigates the complex community of microorganisms in the gastrointestinal tract of newborns and how they establish themselves shortly after birth. By using advanced imaging and metabolomics techniques, the study aims to create a detailed map of the metabolic interactions among these gut bacteria. Understanding these interactions is crucial, as disruptions in this microbial community can lead to significant health issues. The research will focus on identifying the molecular processes that contribute to a healthy gut microbiota during early life.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns aged 0-4 weeks who may be at risk for metabolic disorders or gastrointestinal issues.
Not a fit: Patients outside the newborn age range or those without gastrointestinal concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for newborns by enhancing our understanding of gut microbiota development and its impact on metabolism.
How similar studies have performed: While the study employs novel techniques, previous research has shown that understanding gut microbiota interactions is crucial for health, indicating potential for significant findings.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zackular, Joseph Paul — Children's Hosp of Philadelphia
- Study coordinator: Zackular, Joseph Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.