How gut bacteria changes after weight loss surgery may affect colorectal cancer risk
Official title: Gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery
Funded at Vanderbilt University Medical Center · NIH-10923948 · Data updated 2026-11-12
This study is looking at how changes in the bacteria in your gut after weight loss surgery might affect your chances of getting colorectal cancer, and it’s for people who have had or are considering bariatric surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $688,648 |
| NIH project number | 5R01CA275864-02 |
| Project ID | NIH-10923948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are planning to undergo or have recently undergone bariatric surgery.
✕Less likely to help
Patients who have not had bariatric surgery or those with pre-existing colorectal cancer may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota changes following bariatric surgery and the risk of developing colorectal cancer. By analyzing blood and stool samples from patients over time, the study aims to understand how weight loss and changes in gut bacteria can influence cancer risk. The research will focus on both beneficial and harmful bacteria, as well as bile acids, to determine their roles in cancer development after surgery. Patients will be monitored for various health indicators, including diet and medication use, to gather comprehensive data on these interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing colorectal cancer risk in patients who undergo bariatric surgery.
How similar studies have gone: Other research has shown promising results in understanding the role of gut microbiota in various health conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Yu, Danxia — Vanderbilt University Medical Center
- Study coordinator: Yu, Danxia
Related research
Other NIH-funded projects on the same topics.
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Gut bacteria changes after bariatric surgery and colorectal cancer risk
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How weight-loss (bariatric) surgery changes gut bacteria and colon cancer risk
This project looks at how gut bacteria, bile acids, and other body changes after bariatric surgery might affect future colorectal (colon) cancer risk in adults who had the operation.
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This study is looking at how drinking sugary drinks might be linked to an increase in colorectal cancer in people under 50, using mice to see if these drinks speed up the growth of early cancer signs, and it hopes to find ways that changing our diets could help prevent this type of cancer in younger folks.
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Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.