How gut bacteria and their products affect liver inflammation
Mechanisms of gut microbiota/metabolite interface-mediated hepatic inflammation
['FUNDING_R01'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-11094474
This study is looking at how the bacteria in your gut and what you eat, especially high-fat and high-sugar foods, can affect liver inflammation and diseases like fatty liver, and it's designed for anyone interested in understanding how diet impacts liver health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-11094474 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gut microbiota and liver inflammation, particularly focusing on how dietary factors, like high-fat and high-sugar diets, influence this interaction. The study aims to understand the mechanisms behind liver diseases such as nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) by examining how specific microbes and metabolites affect liver immune responses. Using a mouse model that mimics a typical Western diet, researchers will explore the role of gut-derived components in liver health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with risk factors for liver disease, particularly those with high-fat and high-sugar dietary habits.
Not a fit: Patients with liver diseases unrelated to dietary factors or those who do not consume a Western-type diet may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver diseases related to diet and gut health.
How similar studies have performed: Other research has shown promising results in understanding the gut-liver axis, but this specific approach to studying NASH mechanisms is relatively novel.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, GUANGFU — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: LI, GUANGFU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.