How gut bacteria and stress affect mental health in young people
Host DNA methylation as a mechanism of microbiome influence on internalizing behavior
This study is looking at how stress in early life can change the bacteria in our gut and how that might affect feelings like anxiety and depression in kids and teens, helping us find ways to improve mental health through better gut health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10849679 on NIH RePORTER |
What this research studies
This research investigates the relationship between early life stress, gut microbiome composition, and mental health outcomes such as anxiety and depression in children and adolescents. It aims to understand how stress during critical developmental periods can alter gut bacteria, which may in turn affect brain function and behavior through changes in DNA methylation. By examining these connections, the study seeks to uncover potential biological mechanisms that link gut health and mental health, providing insights into how interventions might be designed. Participants may undergo assessments of their gut microbiome and mental health to contribute to this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 0-21 who are experiencing anxiety or depression.
Not a fit: Patients who do not have anxiety or depression or are outside the age range of 0-21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating anxiety and depression in young people by targeting gut health.
How similar studies have performed: Other research has shown promising results in understanding the gut-brain connection, suggesting that this approach could yield valuable insights.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Lewis, Candace Renee — Arizona State University-Tempe Campus
- Study coordinator: Lewis, Candace Renee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.