How gut bacteria and fiber affect heart health in people with HIV
Official title: Gut microbiota-mediated fiber fermentation in HIV-associated cardiovascular disease
Funded at Cedars-Sinai Medical Center · NIH-11070405 · Data updated 2026-11-12
This study is looking at how the bacteria in the gut of people living with HIV might affect heart health, especially how they change the way fiber from food is turned into helpful substances, which could impact blood pressure and heart disease risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $551,000 |
| NIH project number | 5DP1HL174182-02 |
| Project ID | NIH-11070405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and may be experiencing cardiovascular issues.
✕Less likely to help
Patients who are not living with HIV or those who do not have cardiovascular concerns may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota and cardiovascular disease in individuals living with HIV. It focuses on how the gut bacteria, which are altered in people receiving antiretroviral therapy, affect the fermentation of dietary fiber into beneficial compounds called short-chain fatty acids (SCFAs). By using advanced models and technologies, the study aims to understand how these changes may contribute to increased blood pressure and cardiovascular risks. The findings could lead to new strategies for managing heart health in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health and reduced disease risk for people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in cardiovascular health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Vujkovic-Cvijin, Ivan — Cedars-Sinai Medical Center
- Study coordinator: Vujkovic-Cvijin, Ivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.