How gut bacteria and diet can reduce harmful bacteria's effects
Official title: Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence
Funded at Scripps Research Institute, the · NIH-10978196 · Data updated 2026-11-12
This study is looking at how substances made by our gut bacteria and probiotics can help fight off bad germs that cause infections, with the hope of finding new treatments for people and animals who get sick from these germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | November 10, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $775,779 |
| NIH project number | 5R01AI172915-03 |
| Project ID | NIH-10978196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from bacterial infections or those at risk of such infections.
✕Less likely to help
Patients with viral infections or non-bacterial related health issues may not benefit from this research.
What this research studies
This research investigates how certain metabolites produced by gut microbiota, probiotics, and dietary components can inhibit the harmful effects of enteric pathogens. By using advanced techniques in chemical biology, proteomics, and gene editing, the study aims to identify the specific proteins in bacteria that these metabolites target. Understanding these mechanisms could lead to the development of new treatments to combat bacterial infections in both animals and humans. Patients may benefit from insights that could lead to innovative anti-infective therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the impact of harmful bacterial infections.
How similar studies have gone: Previous research has shown promise in using microbiota metabolites to influence bacterial virulence, suggesting potential for success in this approach.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Hang, Howard C — Scripps Research Institute, the
- Study coordinator: Hang, Howard C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.