How gut bacteria and diet can reduce harmful bacteria's effects
Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10978196
This study is looking at how substances made by our gut bacteria and probiotics can help fight off bad germs that cause infections, with the hope of finding new treatments for people and animals who get sick from these germs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10978196 on ClinicalTrials.gov |
What this research studies
This research investigates how certain metabolites produced by gut microbiota, probiotics, and dietary components can inhibit the harmful effects of enteric pathogens. By using advanced techniques in chemical biology, proteomics, and gene editing, the study aims to identify the specific proteins in bacteria that these metabolites target. Understanding these mechanisms could lead to the development of new treatments to combat bacterial infections in both animals and humans. Patients may benefit from insights that could lead to innovative anti-infective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections or those at risk of such infections.
Not a fit: Patients with viral infections or non-bacterial related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the impact of harmful bacterial infections.
How similar studies have performed: Previous research has shown promise in using microbiota metabolites to influence bacterial virulence, suggesting potential for success in this approach.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HANG, HOWARD C — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: HANG, HOWARD C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.