How gut bacteria and aging cells affect metabolic health in older adults
Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction
This study is looking at how changes in gut bacteria and aging cells affect metabolism in older adults, especially when it comes to high-fat diets, and it will explore whether eating less or trying intermittent fasting can help improve health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11092648 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiome changes and cellular aging in older adults, particularly focusing on how these factors contribute to metabolic dysfunction. The study aims to understand how a high-fat diet influences the presence of aging cells and gut bacteria, and how dietary interventions like caloric restriction and intermittent fasting can improve metabolic health. By using a specialized mouse model, researchers will explore the effects of reducing aging cells on gut bacteria and metabolic function, which could provide insights into potential treatments for age-related metabolic issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing metabolic dysfunction or related health issues.
Not a fit: Patients under the age of 65 or those without metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary strategies that improve metabolic health and longevity in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome and cellular aging, suggesting that this approach could yield significant insights.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Zhou, Yanjiao — University of Connecticut Sch of Med/dnt
- Study coordinator: Zhou, Yanjiao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.