How gut bacteria and aging cells affect metabolic health in older adults
Reciprocal Modulation of the Microbiome and Cellular Senescence in Metabolic Dysfunction
['FUNDING_R01'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-10851976
This study is looking at how changes in gut bacteria and aging cells affect health in older adults, especially when it comes to diet, and it aims to find out if eating less or trying intermittent fasting can help improve their overall health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-10851976 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gut microbiome changes and cellular aging in older adults, particularly focusing on how these factors contribute to metabolic dysfunction. The study aims to understand how a high-fat diet influences the presence of aging cells and gut bacteria, and how dietary interventions like caloric restriction and intermittent fasting can improve metabolic health. By using a specialized mouse model, researchers will explore the potential benefits of reducing aging cells and enhancing beneficial gut bacteria to promote better health outcomes in older populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing metabolic dysfunction or related health issues.
Not a fit: Patients under the age of 65 or those without metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary strategies that improve metabolic health and longevity in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome and cellular aging in health, suggesting that this approach could yield significant insights.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, YANJIAO — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: ZHOU, YANJIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.