How gut bacteria and a 'primed' colon may drive colon polyps
The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-11412577
This project looks at whether certain gut bacteria together with molecular changes in the colon make people more likely to develop colon polyps, especially for those at risk of colorectal cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11412577 on ClinicalTrials.gov |
What this research studies
From a patient's perspective, researchers will compare microbial DNA from people with different kinds of colon polyps and use special germ‑free (gnotobiotic) mice to see how those microbes affect polyp formation. They'll combine detailed metagenomic analysis with statistical methods to understand how a 'primed' colon (molecular changes that make the colon more vulnerable) and specific bacteria interact. The team will analyze samples from a unique human cohort to find microbial patterns linked to aggressive versus slow-growing adenomas. The long-term aim is to translate these findings into microbiome‑based prevention strategies to lower the risk of adenomas and colorectal cancer.
Who could benefit from this research
Good fit: Ideal participants are adults with a history of colorectal adenomas or people undergoing colonoscopy who can provide stool and tissue samples for analysis.
Not a fit: People without colon conditions or who cannot provide the required biological samples are unlikely to receive direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could lead to new microbiome-based ways to prevent colon polyps and reduce colorectal cancer risk.
How similar studies have performed: Previous studies have linked gut bacteria to colon polyps, but turning those links into proven prevention strategies is still new and not yet established.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEY, NEELENDU — FRED HUTCHINSON CANCER CENTER
- Study coordinator: DEY, NEELENDU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.