How gut bacteria affect muscle loss during sepsis

Who could benefit from this research

What this research studies

This research investigates the role of gut microbiota in muscle loss experienced by patients suffering from sepsis. By examining the relationship between specific gut bacteria and body composition, the study aims to understand how these microorganisms influence the body's metabolic response during sepsis. The researchers will utilize advanced sequencing techniques to analyze gut bacteria in human patients and explore potential therapeutic interventions to mitigate muscle loss. The ultimate goal is to develop strategies that can help preserve muscle mass and improve recovery outcomes for sepsis patients.

Why it matters

Where this research is happening

• University of Michigan at Ann Arbor
  Ann Arbor, United States Active

Researchers

• Principal investigator: Dickson, Robert Pickett — University of Michigan at Ann Arbor
• Study coordinator: Dickson, Robert Pickett

Related research

Other NIH-funded projects on the same topics.

• Understanding the Gut Microbiome in Sepsis-Related Kidney Injury

  This research explores how the bacteria in your gut might influence why some people with severe infections develop kidney damage.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11123095

• Understanding how gut bacteria affect muscle loss after sepsis

  This study is looking at how the bacteria in your gut might affect muscle loss after a serious infection called sepsis, and it's for people who are recovering from this condition to help find ways to keep their muscles healthy.

  NIH research University of Iowa · Iowa City, United States · NIH-11062387

• Investigating the gut microbiome's role in kidney injury during sepsis

  This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10995018

• How antibiotics affect the gut bacteria and immune system in premature infants with infections

  This study is looking at how antibiotics affect the gut bacteria and immune system of premature babies who might get infections, using a special mouse model to help understand the best ways to treat these little ones.

  NIH research Washington University · Saint Louis, United States · NIH-10886752

• Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots

  A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.

  NIH research Emory University · Atlanta, United States · NIH-11629726

• STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)

  This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.

  NIH research University of Virginia · Charlottesville, United States · NIH-11617036

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.