How gut bacteria affect motor and cognitive issues linked to cassava consumption
Modulatory Effects of the Functional Gut Microbiome in Relation to Cassava Associated Motor and Neurocognitive Deficits
['FUNDING_CAREER'] · CHILDREN'S RESEARCH INSTITUTE · NIH-10893354
This study is looking at how the bacteria in the gut of children who eat toxic cassava might affect their movement and thinking skills, especially in areas of sub-Saharan Africa where konzo, a serious motor disease, is common, to find ways to help reduce these health problems.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10893354 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the gut microbiome and motor and cognitive deficits associated with the consumption of toxic cassava in children. It focuses on understanding how different gut bacteria profiles may influence susceptibility to conditions like konzo, a motor neuron disease. By analyzing the gut flora of children in regions of sub-Saharan Africa, the study aims to uncover the mechanisms behind these health issues and identify potential dietary or environmental factors that could mitigate risks. The research employs a combination of microbiome analysis and clinical assessments to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years living in regions where cassava is a staple food and who may be at risk for neurocognitive deficits.
Not a fit: Patients who do not consume cassava or who are not from regions affected by konzo may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and interventions that reduce the risk of motor and cognitive impairments in children consuming cassava.
How similar studies have performed: Previous research has indicated significant differences in gut microbiome profiles among populations consuming varying levels of toxic cassava, suggesting that this approach has potential for uncovering important health insights.
Where this research is happening
WASHINGTON, UNITED STATES
- CHILDREN'S RESEARCH INSTITUTE — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRAMBLE, MATTHEW SCOTT — CHILDREN'S RESEARCH INSTITUTE
- Study coordinator: BRAMBLE, MATTHEW SCOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus