How gut bacteria affect memory and thinking as we age
Microbiome Contributions to Age-Associated Cognitive Decline
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PENNSYLVANIA · NIH-11089445
This study is looking at how the tiny germs in our gut might affect our brain health as we get older, especially in relation to memory and thinking skills, and it's aimed at helping older adults who want to keep their minds sharp.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11089445 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the microbiome, the community of microorganisms in our gut, in cognitive decline associated with aging. It explores how changes in gut bacteria may influence brain health and contribute to conditions like Alzheimer's disease. By examining the connections between gut health and cognitive function, the study aims to identify potential interventions that could improve memory and thinking skills in older adults. The research employs various methodologies, including microbiome analysis and animal models, to understand these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing early signs of cognitive decline or those at risk for age-associated dementias.
Not a fit: Patients with cognitive decline due to non-age-related factors, such as traumatic brain injury or acute neurological conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results linking gut health to brain function, suggesting that this approach could yield significant insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COX, TIMOTHY — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: COX, TIMOTHY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.