How gut bacteria affect memory and stress from early life
Gut Microbiome Contributions to Human Episodic Memory and the Role of Early Life Stress
['FUNDING_R21'] · HARVARD UNIVERSITY · NIH-10726345
This study is looking at how the bacteria in our gut might affect our memory, especially for people who have experienced stress early in life, and it aims to find ways to improve memory and mood by understanding these connections better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10726345 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between gut microbiota and episodic memory, particularly focusing on how early life stress influences this relationship. By analyzing the gut bacteria of both healthy individuals and those experiencing depressive symptoms, the study aims to identify specific microbiota profiles that correlate with memory function. The approach involves a large sample size to ensure robust findings, moving beyond previous studies that often relied on small groups and less relevant probiotic interventions. Ultimately, the goal is to develop targeted microbiome interventions that could enhance memory and emotional well-being.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with depressive symptoms and those interested in understanding the impact of gut health on memory.
Not a fit: Patients without any memory issues or depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory and reduce depressive symptoms by targeting gut microbiota.
How similar studies have performed: While there is emerging evidence from animal studies supporting the brain-gut axis, this research aims to explore a relatively novel approach in humans, making it a potentially groundbreaking investigation.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHELPS, ELIZABETH ANYA — HARVARD UNIVERSITY
- Study coordinator: PHELPS, ELIZABETH ANYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.