How gut bacteria affect inflammation and metabolism
Official title: Microbiota-immune interactions that promote intestinal homeostasis
Funded at University of Utah · NIH-11124146 · Data updated 2026-11-12
This study is looking at how certain gut bacteria might help people with inflammatory bowel disease (IBD) and diabetes by using mice to find out which bacteria could prevent these health issues and improve overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | June 15, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $653,023 |
| NIH project number | 5R01AT011423-05 |
| Project ID | NIH-11124146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or those at risk of developing diabetes.
✕Less likely to help
Patients without inflammatory bowel disease or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the relationship between gut bacteria and inflammatory bowel disease (IBD) and its connection to metabolic issues like diabetes. By studying a mouse model that experiences both worsened colitis and obesity, the researchers aim to identify specific bacteria that could help prevent these diseases. They will explore how these bacteria interact with the immune system and contribute to disease development. The goal is to find a defined group of bacteria that could be used for therapeutic interventions to improve health outcomes for patients with IBD and diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or alleviate symptoms of inflammatory bowel disease and diabetes.
How similar studies have gone: Previous studies have shown promising results in using microbiota manipulation to improve health outcomes in related conditions, indicating potential success for this approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Round, June Louise — University of Utah
- Study coordinator: Round, June Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.