How gut bacteria affect immune responses to cholera vaccines
Official title: Interpersonal variation in microbiome structure modulates inter-individual immune responses to Vibrio cholerae
Funded at University of California Riverside · NIH-10991657 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect how well you respond to cholera vaccines, and it's for anyone interested in understanding why some people get better protection from the vaccine than others.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | December 26, 2023 |
| Project end | December 25, 2026 |
| Funding year | 2025 |
| Award (this year) | $32,974 |
| NIH project number | 5F31AI179030-02 |
| Project ID | NIH-10991657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in cholera-endemic regions who are receiving or have received oral cholera vaccines.
✕Less likely to help
Patients who have not been vaccinated against cholera or those with gastrointestinal disorders that significantly alter their microbiome may not benefit from this research.
What this research studies
This research investigates how variations in the gut microbiome influence individual immune responses to cholera vaccines. By analyzing the composition of gut bacteria in different populations, the study aims to understand why some people respond better to oral cholera vaccines than others. The researchers will collect samples and data from participants to identify specific microbial communities that may enhance or hinder vaccine efficacy. This could lead to personalized vaccination strategies based on an individual's gut microbiota.
Why it matters
Potential benefit: If successful, this research could lead to improved cholera vaccine effectiveness tailored to individual microbiome profiles.
How similar studies have gone: Other research has shown that gut microbiota can influence vaccine responses, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Do, Elyza Amber — University of California Riverside
- Study coordinator: Do, Elyza Amber
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.