How gut bacteria affect immune responses related to allergies
Official title: Microbial regulation of intestinal tuft cell homeostasis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11001957 · Data updated 2026-11-12
This study is looking at how certain cells in your gut and the bacteria living there can affect your immune system, especially when it comes to allergies and infections, with the hope of finding new ways to treat these issues for people like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $140,271 |
| NIH project number | 5K01DK135647-03 |
| Project ID | NIH-11001957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with allergic diseases or conditions influenced by type 2 immune responses.
✕Less likely to help
Patients without allergic conditions or those not affected by type 2 immune responses may not benefit from this research.
What this research studies
This research investigates the role of intestinal tuft cells and the gut microbiota in regulating immune responses, particularly those related to allergies and helminth infections. It aims to understand how intestinal stem cells influence tuft cell differentiation and how commensal bacteria affect type 2 immune responses. By exploring these interactions, the research seeks to uncover new mechanisms that could lead to innovative treatments for type 2-driven intestinal diseases. Patients may benefit from insights that could inform microbiota-based therapies for allergic conditions.
Why it matters
Potential benefit: If successful, this research could lead to new microbiota-based treatments for patients suffering from allergic diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Eshleman, Emily M. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Eshleman, Emily M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.