How gut bacteria affect immune responses related to allergies
Microbial regulation of intestinal tuft cell homeostasis
['FUNDING_CAREER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11001957
This study is looking at how certain cells in your gut and the bacteria living there can affect your immune system, especially when it comes to allergies and infections, with the hope of finding new ways to treat these issues for people like you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11001957 on ClinicalTrials.gov |
What this research studies
This research investigates the role of intestinal tuft cells and the gut microbiota in regulating immune responses, particularly those related to allergies and helminth infections. It aims to understand how intestinal stem cells influence tuft cell differentiation and how commensal bacteria affect type 2 immune responses. By exploring these interactions, the research seeks to uncover new mechanisms that could lead to innovative treatments for type 2-driven intestinal diseases. Patients may benefit from insights that could inform microbiota-based therapies for allergic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic diseases or conditions influenced by type 2 immune responses.
Not a fit: Patients without allergic conditions or those not affected by type 2 immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new microbiota-based treatments for patients suffering from allergic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESHLEMAN, EMILY M. — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: ESHLEMAN, EMILY M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease