How gut bacteria affect hormone metabolism and health
Human microbiome metabolites in health and disease
This study looks at how the bacteria in our gut change steroid hormones, especially during pregnancy, to see how these changes might affect our health and immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11041399 on NIH RePORTER |
What this research studies
This research investigates how gut bacteria metabolize steroid hormones, particularly glucocorticoids, into other compounds that may influence health. The project focuses on identifying specific gut bacteria and enzymes responsible for producing progestins, which are important for various bodily functions. By studying these processes in both pregnant and non-pregnant mice, the research aims to understand the role of these metabolites in immune function and metabolism. The findings could provide insights into how gut microbiota impacts hormonal balance and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the relationship between gut health and hormonal balance, particularly those with conditions influenced by steroid hormones.
Not a fit: Patients with no interest in gut microbiome research or those not affected by hormonal imbalances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how gut health influences hormone-related conditions and overall well-being.
How similar studies have performed: Previous research has shown promising results in understanding the gut microbiome's role in hormone metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Devlin, Abigail Sloan — Harvard Medical School
- Study coordinator: Devlin, Abigail Sloan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.