How gut bacteria affect fat absorption and metabolism
Microbial regulation of intestinal lipid metabolism and its physiological consequences
This study is looking at how the bacteria in our gut affect how our bodies handle dietary fats, which could help us understand better ways to manage weight and diabetes for people who are dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10991717 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbiota in regulating how the body absorbs dietary fats and how this process influences overall health. By studying mice and zebrafish, the researchers aim to uncover the mechanisms through which specific bacteria can alter fat metabolism in intestinal cells. The project focuses on understanding how these microbial interactions can lead to changes in energy balance and potentially contribute to conditions like obesity and diabetes. Patients may benefit from insights that could lead to new dietary or therapeutic strategies for managing these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or adult-onset diabetes who may benefit from interventions targeting gut microbiota.
Not a fit: Patients with conditions unrelated to gut health or metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for preventing or treating obesity and diabetes by targeting gut bacteria.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Rawls, John F — Duke University
- Study coordinator: Rawls, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.